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Publication Open Access Evaluation of Physical Activity and Lifestyle Interventions During and After Chemotherapy for Ovarian Cancer: A Systematic Review of Patient Experiences and Clinical Outcomes(Springer Nature, 2026-06-05)Ovarian cancer is a highly lethal gynecological malignancy, with chemotherapy-associated toxicity leading to fatigue, reduced physical function, and poor quality of life. Physical activity and lifestyle interventions may offer supportive benefits, but evidence in ovarian cancer remains limited and heterogeneous. This study aimed to assess how lifestyle modifications and physical activity during and after chemotherapy affect clinical outcomes and patient-reported experiences in women with ovarian cancer. A systematic review was conducted in accordance with PRISMA standards. PubMed, Embase, Scopus, and the Cochrane Library were searched from inception to May 2026. Methodological quality was evaluated using the Cochrane Risk of Bias tool (RoB 2.0) for randomized controlled trials and the Newcastle-Ottawa Scale (NOS) for cohort and prospective studies. Six studies, totaling 724 patients, were included. The interventions included aerobic, resistance, and multimodal exercise routines. Across studies, physical function (six-minute walk test (6MWT): 395-571 m), muscle strength, and mobility were maintained or enhanced. Fatigue levels improved consistently across validated scales in five studies. All studies found that quality of life increased or remained stable. In one study, exercise was linked to improved treatment tolerance, including appropriate chemotherapy dose intensity and lower neurotoxicity. Adherence (81%-92%) and retention (70%-100%) rates demonstrated high feasibility. Physical activity interventions during and after chemotherapy appear to be practical and effective in improving functional outcomes, fatigue, and quality of life in patients with ovarian cancer. More large-scale trials are required to standardize interventions and validate long-term benefits.Publication Metadata only Turning the tide: how will novel diabetes drugs change the future management of cardiovascular disease?(MediNews (Cardiology), 2025-02-04)This article won first prize in the recent British Junior Cardiologists' Association (BJCA) essay competition. Keywords: glucagon-like peptide 1 (GLP-1); heart failure; metabolic syndrome; obesity; sodium-glucose cotransporter 2 (SGLT2); type 2 diabetes mellitus.Publication Metadata only Hydration risk assessment and fluid balance monitoring in older patients at a community hospital(MA Healthcare, 2026-07-03)Background: Adequate hydration and fluid balance are essential for maintaining vital metabolic processes. Accurate fluid balance monitoring is therefore a fundamental component of effective patient care. However, monitoring is often compromised by staff shortages, high workloads, time pressures, and limited training, reducing the time available for ensuring accurate documentation. In addition, poor awareness of its clinical significance, unclear roles and responsibilities, and workplace cultures that do not prioritise accurate recording may contribute to inconsistent practice and poor compliance. Aims: This quality improvement project aimed to improve the identification of patients requiring monitoring and increase the accuracy and completeness of fluid balance charts by 50% within 3 months. Method: Using the Model for Improvement Framework, four Plan-Do-Study-Act (PDSA) cycles were conducted. Interventions included targeted staff training, a simplified fluid balance chart, and amendments to the hydration risk assessment. Data were collected through questionnaires and documentation audits. Results: The project led to 100% of the fluid balance charts meeting predefined standards, improved compliance with hydration care plans, and reduced inappropriate fluid balance chart use. Conclusion: Targeted, sustainable interventions can improve fluid balance monitoring, enhance documentation accuracy, and support safer patient care in a community hospital setting. Keywords: Documentation; Fluid balance; Hydration; Monitoring.Publication Metadata only Validity evidence for an objective scoring tool for endoscopic tip control during snare-tip soft coagulation (with video)(Elsevier, 2026-05-18)Background and aims: Tip control (TC) is a core endoscopic skill, yet objective and practical in vivo assessment tools are lacking. We developed and gathered validity evidence for a scoring method using snare-tip soft coagulation (STSC) of the post-EMR defect margin as a standardized task. Methods: A prospective, single-center observational study of consecutive patients undergoing EMR for large (≥20 mm) nonpedunculated colorectal polyps was conducted. Live or video observers used a web tool to classify STSC applications as correct ("on-margin") or incorrect. Outcomes were accuracy, speed (correct hits/min), z-standardized composite score (z_accuracy + z_speed = performance index), and rater subjective impression. Group differences (experts >500 EMRs vs trainees <50 EMRs) were estimated with generalized linear mixed-effects models, with random intercepts for endoscopist, observer, and procedure. Interrater reliability (intraclass coefficient [2,k]) was calculated. Results: Sixty-eight procedures performed by 14 endoscopists were scored by 19 observers (170 ratings; median 2 per procedure; IQR, 1-3). Experts (n = 3) outperformed trainees (n = 11) for accuracy (adjusted mean, 90.0% vs 81.2%; adjusted mean difference [AMD], +8.9 percentage points [95% CI, 4.6-12.9]; P < .001) and speed (13.3 correct hits/min [95% CI, 11.0-15.6] vs 9.7 [95% CI, 8.0-11.4]; AMD, +3.6 correct hits/min [95% CI, 0.9-6.3]; P = .01). The performance index for experts was significantly higher than for trainees (AMD, +1.4 [95% CI, 0.7-2.2]; P < .001). Overall impression scores also favored experts (AMD, +1.0 points on 0-10 scale [95% CI, 0.5-1.6]; P < .001). ICC(2,k) for overall impression and accuracy was excellent (ICC[2,k] = 0.98 and 0.97, respectively). Convergent validity was demonstrated by significant associations between overall impression and both accuracy (β = 0.8 per 10 percentage points [95% CI, 0.7-1.0]; P < .001) and speed (β= 0.7 per 10 hits/min [95% CI, 0.4-1.0]; P < .001). Conclusions: A simple, in vivo, procedure-level score captured during routine STSC provided an objective measure of endoscopic tip TC, separating experts from trainees.Publication Open Access Improving Mouth Care Standards within our Physical Health, Mental Health and Learning Disabilities Inpatient Areas(Gloucestershire Health and Care NHS Foundation Trust, 2023-05-17)
