MRI and CBCT for lymph node identification and registration in patients with NSCLC undergoing radical radiotherapy

Purpose This study compared MRI to CBCT for the identification and registration of lymph nodes (LN) in patients with locally advanced (LA)-NSCLC, to assess the suitability of targeting LNs in future MR-image guided radiotherapy (MRgRT) workflows. Method Radiotherapy radiographers carried out Visual Grading Analysis (VGA) assessment of image quality, LN registration and graded their confidence in registration for each of the 24 LNs on CBCT and two MR sequences, MR1 (T2w Turbo Spin Echo) and MR2 (T1w DIXON water only image). Results Pre-registration image quality assessment revealed MR1 and MR2 as significantly superior to CBCT in terms of image quality (p ≤ 0.01). No significant differences were noted in interobserver variability for LN registration between CBCT, MR1 and MR2. Observers were more confident in their MR registrations compared to their CBCT based LN registrations (p ≤ 0.02). Summary Interobserver setup correction variability was not found to be significantly different between CBCT and MR. Image quality and registration confidence were found to be superior for MRI sequences. This is a promising step towards MR-guided radiotherapy for the treatment of LA-NSCLC.

Citation

Dubec, M., Brown, S., Chuter, R., Hales, R., Whiteside, L., Rodgers, J., Parker, J., Eccles, C. L., van Herk, M., Faivre-Finn, C., & Cobben, D. (2021). MRI and CBCT for lymph node identification and registration in patients with NSCLC undergoing radical radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 159, 112–118. https://doi.org/10.1016/j.radonc.2021.03.015

DOI

10.1016/j.radonc.2021.03.015

URI

https://hdl.handle.net/20.500.14709/842