Incidence and Prevalence of Complete RPE and Outer Retinal Atrophy secondary to AMD assessed using Optical Coherence Tomography in a population in Gloucestershire, UK.
Mohamed, Quresh Jones, Rebecca Bhowmik, Shaswati Li, Yan Mcfadyen, James Qian, Evelyn
Mohamed, Quresh
Jones, Rebecca
Bhowmik, Shaswati
Li, Yan
Mcfadyen, James
Qian, Evelyn
Date
2024-06
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Conference Abstract
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Abstract
Purpose : There is limited information on the number of patients with foveal and non-foveal geographic atrophy (GA) who may benefit from treatment. We conducted a retrospective, study to assess all patients in Gloucestershire with a diagnosis of AMD using optical coherence tomography (OCT) imaging using Consensus on Atrophy Meeting group (CAM) criteria to estimate incidence and prevalence of GA.
Methods : We analysed all eyes in persons >55 years with diagnosis of AMD on Medisoft electronic medical record seen in Gloucestershire NHS hospitals between 07/01/21-06/30/23.
Graders assessed OCT and infrared images for Complete RPE and Outer Retinal Atrophy (cRORA), foveal involvement and lesion size. Where foveal involvement was noted, graders also assessed the previous OCT from 12 months earlier (±84 days). Eyes were excluded if there were non-AMD causes of atrophy or unassessable/missing images.
A random selection of 5% cases were regraded to assess intergrader agreement.
Results : There were 2847 patients who had a diagnosis of GA in at least one eye. The median age of the patient at first eye diagnosis was 84.8 years (IQR: 79.1 to 89.4).
Estimated prevalence of GA in at least one eye was 1.2% for population of Gloucestershire >55 years, varying from 0.04% in those aged <65 years to 11.2% in those ≥85 years.
The incidence of foveal involving GA in at least one eye was 3.8 per 10000 person-years and the incidence of non-foveal GA was 3.8 per 10000 person years over study period. cRORA was present in 29.1% of eyes with assessable images.
Of those with GA, 48.7% had non-foveal involvement with better LogMAR visual acuity (VA) of 0.3 (IQR: 0.2 to 0.5) compared to 0.76 (IQR 0.4 to 1.2) in eyes with foveal involvement.
There was fair agreement for GA vs non-GA (κ=0.42) and good agreement for foveal vs non-foveal involvement (κ=0.78).
24% patients with GA would have been eligible for the Pegcetaoplan OAKS/DERBY study (aged ≥60 years, VA at the end of the study period ≥24 ETDRS letters and total size of 2.5mm2 to 17.5mm2).
Conclusions : Almost half of the foveal involving GA eyes had a VA at the end of the study period worse than 1.0 LogMAR. Around 13% of eyes with foveal-involving GA maintained VA better than 0.3 LogMAR by the end of the study period.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.
Citation
Mohamed, Q., Javed, U., Norridge, C., Jones, R., Bhowmik, S., Galsworthy, P., ... & Scanlon, P. H. (2024). Incidence and Prevalence of Complete RPE and Outer Retinal Atrophy secondary to AMD assessed using Optical Coherence Tomography in a population in Gloucestershire, UK. Investigative Ophthalmology & Visual Science, 65(7), 1340-1340.
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CC BY-NC-ND 4.0