Raman Spectroscopy: Twenty-five years of concept to clinical application for early diagnosis of pre-cancer in Barrett’s Oesophagus
Day, John Barr, Hugh Kendall, Catherine
Hutchings, Joanne Isabelle, Martin Almond, Mark Pavlou, Alexandros Upchurch, Emma
Day, John
Barr, Hugh
Hutchings, Joanne
Isabelle, Martin
Almond, Mark
Pavlou, Alexandros
Upchurch, Emma
Date
2020-12-01
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Type
Journal Article
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Abstract
Early diagnosis and treatment of all diseases and in particular cancer is important to allow curative treatment. Symptomatic cancer is usually a lethal disease that requires extensive treatment that is enormously challenging for the patient. Over some twenty-five years we have explored the use of Raman to detect molecular changes in precancerous change and cancer of the oesophagus. The aims have been to reduce the subjectivity of histological diagnosis in particular of dysplastic pre invasive cancerous changes in columnar lined (Barrett’s Oesophagus). These changes are often macroscopically invisible and very easily undetectable. Following this we have investigated the development of rapid diagnostic techniques to detect early degeneration in real time without the delays inherent in biopsy and histological analysis. In particular, we have concentrated on the early detection of the macroscopically invisible changes that precede the degeneration to cancer in some patients with Barrett’s Oesophagus. Once these changes are detected the area can we treated using endoscopic techniques and the progression to cancer interrupted without major and life threatening interventions.
Citation
Day, J. C., Stone, N., Barr, H., Kendal, C., Hutchings, J., Isabelle, M., ... & Mohamed, M. N. (2021). Raman Spectroscopy: Twenty-five years of concept to clinical application for early diagnosis of pre-cancer in Barrett’s Oesophagus. Asian Journal of Physics, 30(2), 273-280.