Gloucestershire Evidence & Research Repository

Recent Submissions

  • PublicationOpen Access
    Digital Technology Use and Mental Health Consultations: Survey of the Views and Experiences of Clinicians and Young People
    (JMIR Publications, 2023-04-17) Rifkin-Zybutz, Raphael; Turner, Nicholas; Derges, Jane; Bould, Helen; Sedgewick, Felicity; Gooberman-Hill, Rachael; Linton, Myles-Jay; Moran, Paul; Biddle, Lucy; Bould, Helen; Medical and Dental
    Background: Digital technologies play an increasingly important role in the lives of young people and have important effects on their mental health. Objective: We aimed to explore 3 key areas of the intersection between digital technology and mental health: the views and experiences of young people and clinicians about digital technology and mental health; implementation and barriers to the UK national guidance recommendation-that the discussion of digital technology use should form a core part of mental health assessment; and how digital technology might be used to support existing consultations. Methods: Two cross-sectional web-based surveys were conducted in 2020 between June and December, with mental health clinicians (n=99) and young people (n=320). Descriptive statistics were used to summarize the proportions. Multilinear regression was used to explore how the answers varied by gender, sexuality, and age. Thematic analysis was used to explore the contents of the extended free-text answers. Anxiety was measured using the Generalized Anxiety Disorder Questionnaire-7 (GAD-7). Results: Digital technology use was ubiquitous among young people, with positive and negative aspects acknowledged by both clinicians and young people. Negative experiences were common (131/284, 46.1%) and were associated with increased anxiety levels among young people (GAD-7 3.29; 95% CI 1.97-4.61; P<.001). Although the discussion of digital technology use was regarded as important by clinicians and acceptable by young people, less than half of clinicians (42/85, 49.4%) routinely asked about the use of digital technology and over a third of young people (48/121, 39.6%) who had received mental health care had never been asked about their digital technology use. The conversations were often experienced as unhelpful. Helpful conversations were characterized by greater depth and exploration of how an individual's digital technology use related to mental health. Despite most clinicians (59/83, 71.1%) wanting training, very few (21/86, 24.4%) reported receiving training. Clinicians were open to viewing mental health data from apps or social media to help with consultations. Although young people were generally, in theory, comfortable sharing such data with health professionals, when presented with a binary choice, most reported not wanting to share social media (84/117, 71.8%) or app data (67/118, 56.8%) during consultations. Conclusions: Digital technology use was common, and negative experiences were frequent and associated with anxiety. Over a third of young people were not asked about their digital technology use during mental health consultations, and potentially valuable information about relevant negative experiences on the web was not being captured during consultations. Clinicians would benefit from having access to training to support these discussions with young people. Although young people recognized that app data could be helpful to clinicians, they appeared hesitant to share their own data. This finding suggests that data sharing has barriers that need to be further explored. Keywords: adolescent; anxiety; child; internet; mental health; patient-physician relationship.
  • PublicationMetadata only
    Trichoscopy of Cicatricial Alopecia in Fair and Dark Skin: A Multicenter International Study of the EADV Task Force on Hair Diseases and the IDS Task Force on Trichoscopy
    (Wiley, 2026-05-01) Kelati, Awatef; Waskiel-Burnat, Anna; Apalla, Zoe; Ioannides, Dimitrios; Fernandes Melo, Daniel; Rakowska, Adriana; Rudnicka, Lidia; Faik, Marwa; Meziane, Mariame; Takwale, Anita; Takwale, Anita; Medical and Dental
    Background: Trichoscopy enhances diagnostic accuracy in primary cicatricial alopecias (PCA), yet comparative data on its application across diverse skin phototypes remain limited. Objectives: The aim of this study was to characterize trichoscopic features across various forms of PCAs and compare findings between fair and dark phototypes. Methods: This is a descriptive, multicenter international study analyzing trichoscopic patterns in 1102 patients with PCAs across a range of ethnic backgrounds and skin phototypes. Results: The absence of follicular openings was the most consistent trichoscopic finding across all phototypes. Notable variations in trichoscopic patterns were observed based on skin color. In both fair and dark phototypes, signs of clinical and trichoscopic activity were predominantly observed within the first five years of disease duration, when inflammation is typically more pronounced. Conclusions: Clinicians should be aware of trichoscopic variations both between and within the same PCA according to the phototype. Such awareness enhances the recognition and interpretation of trichoscopic features, particularly during the early and active stages of the disease, and helps guide the selection of optimal biopsy sites across PCA subtypes in both fair and dark skin. This approach can ultimately facilitate histopathological confirmation and support clinical decision-making. Keywords: cicatricial alopecia; dark skin; diagnostic accuracy; fair skin; primary cicatricial alopecia; skin phototype; trichoscopy.
  • PublicationMetadata only
    Management of paracetamol (acetaminophen) toxicity
    (BMJ Publishing Group, 2026-04-30) Humphries, Chris; Gawarammana, Indika; Gillings, Marianne; Riddell, Alice; Dear, James; Gillings, Marianne; Medical and Dental
    No abstract available
  • PublicationOpen Access
    Genomic and spatial analysis of local recurrences following risk-adapted breast radiotherapy in the IMPORT trials
    (BioMed Central, 2026-04-25) Lightowlers, Sara; Roman-Escorza, Maria; Welsh, Ceilidh; Bliss, Judith; Caroll, Jason; Chan, Charlie; Harrison, Karl; Haviland, Joanne; Healy, Nuala; Jefford, Monica; Jena, Rajesh; Kirby, Anna; Kirwan, Cliona; Provenzano, Elena; Sydenham, Mark; Syndikus, Isabel; Tanner, James; Woitek, Ramona; Coles, Charlotte; Sawyer, Elinor; Chan, Charlie; Medical and Dental
    No abstract available
  • PublicationMetadata only
    Impact of visit schedule on estimated success rates in glaucoma surgical studies
    (BMJ Publishing Group, 2026-04-29) Rabiolo, Alessandro; Khaliliyeh, Daniela; Jin, Sang Wook; Morales, Esteban; Rossetti, Luca; Anand, Nitin; Montesano, Giovanni; Oddone, Francesco; Capriolo, Joseph; De Cilla, Stefano; Anand, Nitin; Medical and Dental
    Aims: To evaluate how different methods of managing multiple visits within predefined time windows affect intraocular pressure (IOP)-based success rates in glaucoma surgery studies. Methods: We applied literature-based high IOP failure criteria to two cohorts of 934 and 1760 eyes undergoing trabeculectomy and deep sclerectomy (DS) with median follow-up of 41.4 months and 45.4 months, respectively. Failure was defined by IOP thresholds, loss of light perception, hypotony requiring revision or additional IOP-lowering surgery. Visits were grouped into guideline-based windows and six visit-managing strategies were applied to all visits, mean, lowest, highest, median and closest IOP to the recommended time point. We calculated Kaplan-Meier success rates for each visit-managing strategy. Visual field (VF) analysis was conducted on patients in the trabeculectomy cohort with ≥4 VFs in ≥2 years post-surgery. Results: For the 21 mm Hg threshold, 5-year success was highest with the lowest IOP (trabeculectomy: 54.8%; DS: 74.5%), followed by closest IOP (trabeculectomy: 46.7%; DS: 67.6%), the median (trabeculectomy: 46.9%; DS: 69.1%) and mean IOP (trabeculectomy: 46.3%; DS: 68.6%). Success rates were lower with peak IOP (trabeculectomy: 39.3%; DS: 60.4%) and all visits IOP (trabeculectomy: 38.8%; DS: 61.0%). In the VF subset, eyes classified as failures demonstrated significantly faster mean deviation (MD) progression than those classified as successes although substantial overlap in the distribution of MD rates persisted between groups under every strategy. Conclusions: Visit-managing strategies influence reported success rates. None of the evaluated approaches achieved a clear separation in VF progression rates, underscoring the inherent limitations of IOP-threshold-based classifications. Keywords: Clinical Trial; Filtering Surgery; Glaucoma; Intraocular pressure.