Browsing by Journal Title "Progress in Neurology and Psychiatry"
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Publication A qualitative evaluation of a research champions initiative in an NHS Trust(Wiley, 2022-11-08) Hepburn, Zoe; Broomfield, Katherine; Dowdeswell, Nicola; Harvey, Marelle; Lane, Jessica; Walker, Mark; Kuruvilla, Tarun; Hepburn, Zoe; Broomfield, Katherine; Dowdeswell, Nicola; Harvey, Marelle; Lane, Jessica; Walker, Mark; Kuruvilla, Tarun; Admin and Clerical; Additional Professional Scientific and Technical; Allied Health Professional; Nursing and Midwifery Registered; Medical and DentalPromoting research in NHS trusts is known to be beneficial for patient outcomes and clinicians’ attitudes towards research and recruitment to studies. Here the authors report their evaluation of a research champions initiative at a specialist mental health and community services trust.Publication Aducanumab and disease modifying treatments for Alzheimer's disease(Wiley, 2021-08-10) Thomas, Emily; Wasunna-Smith, Brenda; Kuruvilla, Tarun; Thomas, Emily; Wasunna-Smith, Brenda; Kuruvilla, Tarun; Medical and DentalAducanumab has recently been licensed by the Food and Drug Administration (FDA) in the USA under its ‘accelerated approval’ pathway (to provide earlier access to treatments that fulfil an unmet need based on a surrogate endpoint) for treatment of Alzheimer's disease. This was a controversial decision, and the licence is subject to the outcome of further phase IV trials. Results will be eagerly anticipated, especially by the estimated 50 billion people worldwide currently living with dementia.1 The drugs success could pave the way for a new era in treatments at a time where existing therapies only offer symptomatic treatment to slow progression.Publication Artificial intelligence as an aid to diagnosing dementia: an overview(Wiley, 2021-08-10) Dashwood, Mark; Churchhouse, Gabrielle; Young, Matilda; Kuruvilla, Tarun; Dashwood, Mark; Churchhouse, Gabrielle; Young, Matilda; Kuruvilla, Tarun; Medical and DentalArtificial intelligence (AI) is showing huge promise in assisting with early diagnosis of dementia, which would yield clear benefits in optimising the quality of life of those with dementia and their carers. In this review, the authors provide an overview of AI technology, its applications and implications for clinical practice. Consideration is given to ethical issues and future challenges.Publication Blood-based biomarkers for Alzheimer's disease(Wiley, 2022-11-08) Chohan, Priyanka; Dashwood, Mark; Theodoulou, George; Reed, Hannah; Kuruvilla, Tarun; Dashwood, Mark; Kuruvilla, Tarun; Medical and DentalBlood-based biomarkers for identifying Alzheimer's disease (AD) pathology have been of considerable interest over the past decade and can offer a significant advantage over the currently available and validated cerebrospinal fluid and positron emission tomography biomarkers in terms of cost, invasiveness and accessibility. This review explores the role of three blood-based biomarkers; plasma amyloid β, tau and neurofilament light chain, and their combination, in the identification of AD pathology and how they may be utilised in clinical practice.Publication Dialysis with bipolar affective disorder: experience of competing treatments(Wiley, 2023-08-09) Abbey, Emma; Jenkins, James; Abbey, Emma; Jenkins, James; Medical and Dental; Patient and Community PartnersThe interaction of several serious illnesses presents considerable difficulty for both clinicians and patients, no matter what the coexisting diseases are. This results in huge anxiety for patients and worsens the difficulties understanding the risks and benefits of the treatment of each disorder. The authors present the clinical scenario where dialysis was commenced while sodium valproate was being taken for bipolar affective disorder, demonstrating the interface between bipolar affective disorder and renal failure and how their treatments caused deterioration in the comorbid condition. This case challenges accepted wisdom regarding the effects of dialysis on the sodium valproate levels in the body and discusses key clinical management issues.Publication Dissociative identity disorder: areview of the diagnosis that divides(Wiley, 2024-05-14) Young, Matilda; Almaskati, Mazen; Vrabtchev, Svetlin; Kuruvilla, Tarun; Young, Matilda; Almaskati, Mazen; Vrabtchev, Svetlin; Kuruvilla, Tarun; Additional Professional Scientific and Technical; Medical and DentalThe diagnosis of dissociative identity disorder (DID) has been associated with controversy and remains an area of dispute among clinicians to this day. This review explores the evolution of the diagnosis and how it is currently described and understood in the International Classification of Diseases (ICD-11) and Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Also considered, are recent implications for clinical practice, treatment recommendations and the potential for any medicolegal issues to emerge.Publication Lecanemab for Alzheimer's disease: new hope or another false dawn?(Wiley, 2023-02-09) Dashwood, Mark; Kuruvilla, Tarun; Dashwood, Mark; Kuruvilla, Tarun; Medical and DentalNo abstract availablePublication New mania post acoustic neuroma resection: more than a coincidence(Wiley, 2023-10-31) Pulley, Imogen; Pulley, Imogen; Medical and DentalMood disorder is a rare complication of acoustic neuroma resection, and therefore unlikely to be listed as a possible risk on a preoperative consent form. However, the occurrence of this has been recognised since as far back as 1914. This case study reports the new presentation of mania in a 65-year-old woman, seven weeks after surgical removal of an acoustic neuroma. The case study explores whether the acoustic neuroma and its surgical management could be directly causative of her psychiatric disorder, or whether it simply represents a psychological trigger in a susceptible patient.Publication The Role of Hormone Replacement Therapy (HRT) for the Prevention of Alzheimer's Disease in Postmenopausal Women(Wiley, 2024-10-01) Littleford, Karla; Tyler, Laura; Dashwood, Mark; Reed, Hannah; Kuruvilla, Tarun; Tyler, Laura; Dashwood, Mark; Kuruvilla, Tarun; Medical and DentalAlzheimer's disease (AD) disproportionately affects women and, in 2022, was the leading cause of female deaths. It has major psychosocial, physical and economic impacts which will become more pronounced with an ageing population. Current treatments focus on symptom control and do not affect disease course. Emerging evidence suggests that the prescription of perimenopausal hormone replacement therapy (HRT) may prevent the development of AD. The objective of this narrative review is to synthesise and analyse relevant literature regarding HRT and AD prognosis in pre- and postmenopausal women to establish the current knowledge and provide a foundation for future research.Publication Trauma-informed approach to managing behaviour in dementia(Wiley, 2024-05-14) Lewington, Kate; Berragan, Liz; Kuruvilla, Tarun; Lewington, Kate; Kuruvilla, Tarun; Nursing and Midwifery Registered; Medical and DentalCauses of behaviour that challenge in dementia are often thought to be due to reversible factors, such as a urine infection or disrupted sleep-wake cycle. In this review, the authors consider a definition of behaviour that challenges commonly cited causes and management models. Finally, recommendations for an alternative view and subsequent approach to managing behaviour that challenges are suggested.