Nerve biopsy in T-cell lymphoma with neurolymphomatosis: where and when
Pipis, Menelaos Jaunmuktane, Zane Marafioti, Teresa Brandner, Sebastian D'Sa, Shirley Lunn, Michael Cwynarski, Kate Fialho, Doreen Shah, Sachit
Pipis, Menelaos
Jaunmuktane, Zane
Marafioti, Teresa
Brandner, Sebastian
D'Sa, Shirley
Lunn, Michael
Cwynarski, Kate
Fialho, Doreen
Shah, Sachit
Gloucestershire Author
Date
2024-01-25
Journal Title
Type
Journal Article
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Abstract
Peripheral T-cell lymphomas are rare heterogeneous haematological malignancies that may also involve peripheral nerves in a very small subset of cases. We report a patient with a diagnostically challenging cutaneous T-cell lymphoma and multifocal mononeuropathies in whom a targeted nerve biopsy identified lymphomatous infiltration of nerves and expedited combination treatment with chemotherapy and an autologous stem cell transplant. She showed an excellent response with a complete metabolic response on positron emission tomography imaging and significant clinical improvement, maintained 5 years post-treatment.